These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
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NM_001164623.3 → NP_001158095.1 protein argonaute-2 isoform 2
Status: REVIEWED
Description Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3′ coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1. Source sequence(s) AC067931, AC107375 Consensus CDS CCDS55279.1 UniProtKB/TrEMBL A4FVC0 Related ENSP00000430176.1, ENST00000519980.5 Conserved Domains (4) summary cd02846Location:227 → 347 PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. … cd04657Location:392 → 783 Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of … pfam08699Location:176 → 226 ArgoL1; Argonaute linker 1 domain pfam16486Location:92 → 166 ArgoN; N-terminal domain of argonaute
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NM_012154.5 → NP_036286.2 protein argonaute-2 isoform 1
See identical proteins and their annotated locations for NP_036286.2
Status: REVIEWED
Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Source sequence(s) AC067931, AC107375 Consensus CDS CCDS6380.1 UniProtKB/Swiss-Prot Q8TCZ5, Q8WV58, Q96ID1, Q9UKV8 UniProtKB/TrEMBL A4FVC0 Related ENSP00000220592.5, ENST00000220592.10 Conserved Domains (4) summary cd02846Location:227 → 347 PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. … cd04657Location:392 → 817 Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the … pfam08699Location:176 → 226 ArgoL1; Argonaute linker 1 domain pfam16486Location:92 → 166 ArgoN; N-terminal domain of argonaute
